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Macrolides

Macrolides: Azithromycin, Erythromycin, and Clarithromycin

Broad-spectrum – Gram-positive bacteria – Neisseria – Legionella – Mycoplasma – Chlamydiae – Treponema – Clarithromycin and Azithromycin are effective against some Mycobacteria.

– Binds the 50S subunit Block translocation and protein synthesis

– Gastrointestinal upset due to increased motility – QT prolongation – Hepatotoxicity